Simpson, 61, who will be eligible for parole after 2017, was led away in handcuffs and shackles following the sentencing before Judge Jackie Glass.
Simpson's co-defendant, Clarence "C.J." Stewart, was sentenced to at least 15 years behind bars.
Among those in the courtroom to hear the sentencing were Fred and Kim Goldman, the father and sister of murder victim Ron Goldman.
Goldman and Nicole Brown Simpson were murdered in June of 1994, a crime O.J. Simpson was found not guilty of a year later.